A novel RNA helicase gene tightly linked to the Triplo-lethal locus of Drosophila.

doi:10.1093/nar/18.18.5489

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Article

A novel RNA helicase gene tightly linked to the Triplo-lethal locus of Drosophila.

Nucleic acids research - 25 Sept 1990

Dorer D R, Christensen A C, Johnson D H

Abstract excerpt

The Triplo-lethal (Tpl) locus of Drosophila is the only known locus which is lethal when present in three copies rather than the normal two. After recovering a hybrid-dysgenesis-induced mutation of Tpl we used a rapid combination of transposon tagging, chromosome microdissection and PCR to clone the P element that had transposed into the Tpl region. That P element is located within the gene for a new and unique...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cloning, Molecular
DNA
DNA Transposable Elements
Drosophila
Exons
Genes
Genetic Linkage
Introns
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nucleic Acid Hybridization

Phenotype

Polymerase Chain Reaction

RNA Nucleotidyltransferases

Restriction Mapping

Source

Open in PubMed Open full text

Identifiers

PMID: 2170937
DOI: 10.1093/nar/18.18.5489
PMCID: PMC332228

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2170937-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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