Article
Rapid screening method of abnormal insulin-receptor gene expression: allele-specific oligonucleotide hybridization by using silent polymorphisms.
Biochimica et biophysica acta - 30 Apr 1993
Imano E, Kawamori R, Iwama N, Umayahara Y, Yamasaki Y, Kamada T
Abstract excerpt
An asymmetrical reduction in the levels of the insulin receptor mRNA transcribed from one allele was reported in some patients with severe insulin resistance and non-insulin-dependent diabetes mellitus (NIDDM). To detect this abnormality, we designed the less laborious method; Allele-specific oli...
Topics
- Alleles
- Base Sequence
- Diabetes Mellitus, Type 2
- Gene Expression
- Humans
- Insulin Resistance
- Molecular Sequence Data
- Mutation
- Nucleic Acid Hybridization
- Polymorphism, Genetic
- RNA, Messenger
- Receptor, Insulin