Article
Abnormal messenger ribonucleic acid (mRNA) transcribed from a mutant insulin receptor gene in a patient with type A insulin resistance.
Diabetologia - 1 Jul 1992
Shimada F, Suzuki Y, Taira M, Hashimoto N, Nozaki O, Makino H, Yoshida S
Abstract excerpt
In a previous report on a 16-year-old Japanese girl with type A insulin resistance, we found that one allele of the insulin receptor gene was inherited from her mother and contained a 1.2 kilobase pair deletion which removed the 14th exon in the beta subunit. We extended investigation of the prob...
Topics
- Adolescent
- Alleles
- Amino Acids
- Base Sequence
- Blotting, Northern
- Chromosome Deletion
- Exons
- Female
- Humans
- Insulin Resistance
- Introns
- Japan
- Molecular Sequence Data
- Mutation
- RNA, Messenger
- Receptor, Insulin
- Restriction Mapping
- Transcription, Genetic