Article
Cloning and characterization of a vacuolar ATPase A subunit homologue from Plasmodium falciparum.
Molecular and biochemical parasitology - 1 Apr 1993
Karcz S R, Herrmann V R, Cowman A F
Abstract excerpt
The distribution of the antimalarial drug chloroquine is determined to a significant extent by a transvacuolar pH gradient in Plasmodium falciparum. A proton pump similar to the vacuolar ATPase found in many cell types has been suggested to maintain a pH gradient across the membranes of acidic compartments in the parasite. In order to understand and define the components involved in the mechanism of acidification...
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