Glutathione S-transferase mu polymorphism does not explain variation in nitroglycerin responsiveness.

doi:10.1038/clpt.1993.52

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Article

Glutathione S-transferase mu polymorphism does not explain variation in nitroglycerin responsiveness.

Clinical pharmacology and therapeutics - 1 Apr 1993

Haefeli W E, Srivastava N, Kelsey K T, Wiencke J K, Hoffman B B, Blaschke T F

Abstract excerpt

OBJECTIVE: To determine whether the considerable interindividual variability in nitroglycerin-induced venodilation in humans is related to the polymorphic expression of the mu class of glutathione S-transferase (GST mu). Recently vascular glutathione S-transferase (EC 2.5.1.18) of the mu-class (G...

Topics

Adult
Dose-Response Relationship, Drug
Female
Genotype
Glutathione Transferase
Hand
Humans
Isoenzymes
Male
Middle Aged
Nitroglycerin
Polymerase Chain Reaction
Polymorphism, Genetic
Vasodilation

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