Article
Extracellular matrix components induce endocrine differentiation in vitro in NCI-H716 cells.
The American journal of pathology - 1 Mar 1993
de Bruïne A P, Dinjens W N, van der Linden E P, Pijls M M, Moerkerk P T, Bosman F T
Abstract excerpt
Endocrine cells occur in +/- 30% of colorectal adenocarcinomas. The significance of this phenomenon in terms of tumor behavior is still controversial. Endocrine differentiation in colorectal cancer cell lines is almost confined to tumor xenografts in vivo, suggesting that endocrine differentiatio...
Topics
- Adenocarcinoma
- Animals
- Blotting, Northern
- Cecal Neoplasms
- Cell Differentiation
- Chromogranin A
- Chromogranins
- Endocrine Glands
- Extracellular Matrix
- Humans
- Immunohistochemistry
- Mice
- Mice, Mutant Strains
- Neoplasm Transplantation
- Phenotype
- Transplantation, Heterologous
- Tumor Cells, Cultured