Article
Impaired peripheral thyroid hormone metabolism in genetic obesity.
Endocrinology - 1 Mar 1993
Katzeff H L, Selgrad C
Abstract excerpt
The obese Zucker rat has alterations in thyroid hormone metabolism resulting in a lower serum T3 concentration and T3 plasma appearance rate compared to its lean littermates. This study was undertaken to measure the contribution of specific nonthyroidal tissues to the total production of T3 in vivo in the Zucker fatty rat. Simultaneous pulse kinetic studies of T4 and T3 were performed in lean and obese Zucker...
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