Prevalence of familial hypercholesterolemia among young north Karelian patients with coronary heart disease: a study based on diagnosis by polymerase chain reaction.

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Article

Prevalence of familial hypercholesterolemia among young north Karelian patients with coronary heart disease: a study based on diagnosis by polymerase chain reaction.

Journal of lipid research - 1 Feb 1993

Koivisto U M, Hämäläinen L, Taskinen M R, Kettunen K, Kontula K

Abstract excerpt

Two deletions of the low density lipoprotein (LDL) receptor gene account for about 90% of the mutations that cause familial hypercholesterolemia (FH) in eastern Finland. The FH-Helsinki mutation deletes exons 16, 17 and a portion of exon 18, while the FH-North Karelia allele is characterized by a...

Topics

Adult
Base Sequence
Cholesterol, LDL
Coronary Disease
DNA
Exons
Female
Finland
Gene Deletion
Humans
Hyperlipoproteinemia Type II
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Molecular Sequence Data

Mutation

Myocardial Infarction

Polymerase Chain Reaction

Receptors, LDL

Source

Open in PubMed

Identifiers

PMID: 8429261

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8429261-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Prevalence of familial hypercholesterolemia among young north Karelian patients with coronary heart disease: a study based on diagnosis by polymerase chain reaction.PMID 8429261Read ↗

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