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Article

Characterization of dysfunctional factor VIII molecules.

Methods in enzymology - 1 Jan 1993

Hoyer L W

Abstract excerpt

Immunopurification and characterization of dysfunctional factor VIII-like molecules in CRM-positive and CRM-reduced hemophilia A permit correlation of structural changes with molecular defects. The technique described here is sufficiently sensitive to characterize the molecular mass and enzymatic fragments of the factor VIII chains in patients with as little VIII: Ag as 0.05 units/ml. Specific abnormalities have...

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Identifiers

PMID: 8412792
DOI: 10.1016/0076-6879(93)22012-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Characterization of dysfunctional factor VIII molecules.PMID 8412792Read ↗

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Reduced activation of the Gla19Ala FX variant via the extrinsic coagulation pathway results in symptomatic CRMred FX deficiency.Semantic proximity Read ↗

Defining ‘full‐length’ recombinant factor VIII: a comparative structural analysisSemantic proximity Read ↗

Molecular basis of inherited factor XIII deficiency: identification of multiple mutations provides insights into protein function.Semantic proximity Read ↗

Molecular genetic analysis of a novel form of haemophilia A characterized by the variable expression of factor VIII.Semantic proximity Read ↗

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