Article
Organization of the variant domains of alpha satellite DNA on human chromosome 21.
Journal of molecular evolution - 1 Aug 1993
Marçais B, Laurent A M, Charlieu J P, Roizès G
Abstract excerpt
The de novo creation of long, homogeneous, satellite DNA domains was postulated previously to occur by saltatory amplification. In this paper, pulsed field gel electrophoresis analysis of the alpha satellite DNA block organization of the human chromosome 21 supports this hypothesis. Double-dimens...
Topics
- Base Sequence
- Biological Evolution
- Chromosomes, Human, Pair 21
- DNA, Satellite
- Electrophoresis, Gel, Pulsed-Field
- Female
- Gene Amplification
- Genetic Variation
- Genetics, Population
- Genome, Human
- Humans
- Male