Article
Founder effect in a Belgian-Dutch fragile X population.
Human genetics - 1 Oct 1993
Buyle S, Reyniers E, Vits L, De Boulle K, Handig I, Wuyts F L, Deelen W, Halley D J, Oostra B A, Willems P J
Abstract excerpt
For many years, the high prevalence of the fragile X syndrome was thought to be caused by a high mutation frequency. The recent isolation of the FMR1 gene and identification of the most prevalent mutation enable a more precise study of the fragile X mutation. As the vast majority of fragile X patients show amplification of an unstable trinucleotide repeat, DNA studies can now trace back the origin of the fragile...
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