Article
Isolation of a mitotic-like cyclin homologue from the protozoan Trypanosoma brucei.
Gene - 30 Sept 1993
Affranchino J L, González S A, Pays E
Abstract excerpt
Activation of the p34cdc2 protein kinase (PK) at different stages of the eukaryotic cell cycle is controlled by interaction with regulatory proteins known as cyclins (CYCs). Using a probe obtained by PCR amplification, we have isolated from the protozoan, Trypanosoma brucei, a cDNA clone encoding a CYC homologue. The amino acid sequence deduced for this gene (CYC1) shares structural homology with A- and B-type...
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