Inhibition of Migration of Neural Crest-Derived Cells by the Abnormal Mesenchyme of the Presumptive Aganglionic Bowel of ls/ls Mice: Analysis with Aggregation and Interspecies Chimeras

Abstract excerpt

The terminal bowel is congenitally aganglionic in ls/ls mice. The condition has been associated with an overabundance of laminin and other matrix molecules. Aggregation ls/ls<==>C3H chimeric mice and interspecies mouse<==>quail chimeras were constructed to test the hypothesis that the aganglionosis arises because the ls/ls gut and not the neural crest is abnormal. Demonstration of beta-glucuronidase activity...

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