Modulation of skeletal muscle sodium channels by human myotonin protein kinase.

doi:10.1172/JCI117931

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Article

Modulation of skeletal muscle sodium channels by human myotonin protein kinase.

The Journal of clinical investigation - 1 May 1995

Mounsey J P, Xu P, John J E, Horne L T, Gilbert J, Roses A D, Moorman J R

Abstract excerpt

In myotonic muscular dystrophy, abnormal muscle Na currents underlie myotonic discharges. Since the myotonic muscular dystrophy gene encodes a product, human myotonin protein kinase, with structural similarity to protein kinases, we tested the idea that human myotonin protein kinase modulates skeletal muscle Na channels. Coexpression of human myotonin protein kinase with rat skeletal muscle Na channels in Xenopus...

Topics

Animals
Brain
Fetus
Humans
Membrane Potentials
Muscle, Skeletal
Muscular Dystrophies
Mutation
Myocardium
Myotonin-Protein Kinase
Oocytes
Patch-Clamp Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphorylation

Protein Kinases

Protein Serine-Threonine Kinases

RNA, Messenger

Rats

Repetitive Sequences, Nucleic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 7738201
DOI: 10.1172/JCI117931
PMCID: PMC295863

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7738201-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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