Article
Misclassification of genetic susceptibility biomarkers: implications for case-control studies and cross-population comparisons.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2000
Rothman N, Stewart W F, Caporaso N E, Hayes R B
Abstract excerpt
Phenotype and genotype markers of genetic susceptibility are of increasing interest in case-control studies of cancer. It is well established that bias to the odds ratio is caused by less-than-perfect assay sensitivity and specificity and varies with risk factor prevalence. As such, the observed...
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