Article
Misclassification of genetic susceptibility biomarkers: implications for case-control studies and cross-population comparisons.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2000
Rothman N, Stewart W F, Caporaso N E, Hayes R B
Abstract excerpt
Phenotype and genotype markers of genetic susceptibility are of increasing interest in case-control studies of cancer. It is well established that bias to the odds ratio is caused by less-than-perfect assay sensitivity and specificity and varies with risk factor prevalence. As such, the observed variation in odds ratio between studies of genetic markers and cancer risk may be real, or may be attributed, in part,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.