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Article

Genetic and epigenetic mechanisms for the limited lifespan and ageing of normal, diploid cells.

Patologia polska - 1 Jan 1993

Srebro Z

Abstract excerpt

The genetic basis of the limited lifespan and apparently programmed number of divisions in normal, diploid cells is discussed. Two different mechanisms may underlie a programmed inhibition of cell divisions before they age and die: 1. A genetic mechanism involving the CpG sequence in promotor regions of genes. Inactive, but gradually activated basic function genes such as ribosomal and energy metabolism genes,...

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PMID: 8309730

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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