Article
The ins/del polymorphism in the signal sequence of apolipoprotein B has no effect on lipid parameters.
Clinica chimica acta; international journal of clinical chemistry - 30 Sept 1993
Gaffney D, Freeman D J, Shepherd J, Packard C J
Abstract excerpt
The 'ins/del' polymorphism in the signal sequence of apolipoprotein B alters the hydrophobicity of the signal sequence and therefore would be expected to affect the rate of production of apolipoprotein B (apo B) and the plasma concentrations of lipoproteins containing this apolipoprotein. We soug...
Topics
- Apolipoproteins B
- Gene Frequency
- Genotype
- Humans
- Hypercholesterolemia
- Lipoproteins
- Male
- Middle Aged
- Polymorphism, Genetic
- Protein Sorting Signals
- Random Allocation
- Sequence Deletion
- Triglycerides