Article
Examination of human tumors for rhoA mutations.
Oncogene - 1 Jan 1994
Moscow J A, He R, Gnarra J R, Knutsen T, Weng Y, Zhao W P, Whang-Peng J, Linehan W M, Cowan K H
Abstract excerpt
rhoA encodes a ras-related GTP-binding protein that is thought to play a role in cytoskeletal organization. Recent evidence has suggested both that rhoA could act either as a dominant oncogene, since transfection of both normal and activated rho genes confer a transformed phenotype on fibroblast cells in culture, or as a recessive tumor suppressor gene, by virtue, in part, of its chromosomal location at 3p21, a...
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