Antibody of patients with Guillain-Barré syndrome mediates complement-dependent cytolysis of rat Schwann cells: susceptibility to cytolysis reflects Schwann cell phenotype.

Abstract excerpt

We previously observed that demyelination of dissociated dorsal root ganglion cultures by acute phase serum of some Guillain Barré syndrome (GBS) patients was associated with cytolysis of rat Schwann cells (SC) not committed to myelination. In this study, to determine if SC cytolysis was antibody...

Topics

• Animals
• Antibodies
• Cells, Cultured
• Complement System Proteins
• Cytotoxicity, Immunologic
• Humans
• Immunoglobulin M
• Phenotype
• Polyradiculoneuropathy
• Rats
• Rats, Sprague-Dawley
• Schwann Cells