Article
Distribution of androgen receptor CAG repeat polymorphism in Chinese schizophrenia and its correlation with age at onset.
Psychoneuroendocrinology - 1 Feb 2006
Tsai Shih-Jen, Hong Chen-Jee, Liao Ding-Lieh, Chiang Chih-Hung
Abstract excerpt
The action of androgens is mediated by the androgen receptors (ARs), which are located throughout the brain. The AR gene is implicated in the pathogenesis of schizophrenia because male siblings with schizophrenia share alleles at this gene at a rate higher than chance predicts, and differences in sex hormone function may explain the gender difference in schizophrenic manifestations. Since the shorter alleles of...
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