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Article

Biological effects of stable overexpression of aromatase in human hormone-dependent breast cancer cells.

British journal of cancer - 1 Jan 1994

Macaulay V M, Nicholls J E, Gledhill J, Rowlands M G, Dowsett M, Ashworth A

Abstract excerpt

Aromatase is a key enzyme in the conversion of androstenedione and testosterone to oestrone and oestradiol. Intratumoral aromatase activity is expressed by around 70% of breast carcinomas, but it is not clear what effect this has on the tumour phenotype. To address this question we expressed huma...

Topics

Animals
Aromatase
Base Sequence
Breast Neoplasms
CHO Cells
Cricetinae
DNA, Complementary
Enzyme Stability
Gene Expression
Humans
Molecular Sequence Data
Neoplasms, Hormone-Dependent

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

RNA, Messenger

Receptors, Estrogen

Transfection

Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 8286214
DOI: 10.1038/bjc.1994.12
PMCID: PMC1968759

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8286214-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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