Article
Biological effects of stable overexpression of aromatase in human hormone-dependent breast cancer cells.
British journal of cancer - 1 Jan 1994
Macaulay V M, Nicholls J E, Gledhill J, Rowlands M G, Dowsett M, Ashworth A
Abstract excerpt
Aromatase is a key enzyme in the conversion of androstenedione and testosterone to oestrone and oestradiol. Intratumoral aromatase activity is expressed by around 70% of breast carcinomas, but it is not clear what effect this has on the tumour phenotype. To address this question we expressed human aromatase in hormone-dependent MCF-7 breast cancer cells. Clone Arom. 1 expressed aromatase at 1,000 times the...
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