Article
Defective receptors for platelet-derived growth factor AA in human fibroblasts with mutant insulin receptors.
Biochemical and biophysical research communications - 15 Dec 1993
Longo N
Abstract excerpt
Leprechaunism is an inherited disorder characterized by growth restriction and severe insulin resistance and caused by mutations in the insulin receptor gene. Cells from these patients have defective insulin binding. Fibroblasts from some patients have concomitant defects in other tyrosine kinase...
Topics
- Abnormalities, Multiple
- Becaplermin
- DNA
- Epidermal Growth Factor
- Fibroblasts
- Humans
- Insulin
- Insulin-Like Growth Factor I
- Kinetics
- Mutation
- Platelet-Derived Growth Factor
- Proto-Oncogene Proteins c-sis
- Receptor, Insulin
- Receptors, Platelet-Derived Growth Factor
- Recombinant Proteins
- Reference Values
- Skin
- Thymidine