Article
An inborn error in epidermal growth factor prohormone metabolism in a mouse model of autosomal recessive polycystic kidney disease.
Biochemical and biophysical research communications - 29 Oct 1993
Lakshmanan J, Fisher D A
Abstract excerpt
The C57BL/6J CPK heterozygous breeders secrete in urine a variant EGF-prohormone with a molecular mass of 154 kDa in addition to the normal 165 kDa EGF-prohormone. The 154 kDa prohormone is secreted as a heterodimer with the normal 165 kDa prohormone. The phenotypically normal littermates, like t...
Topics
- Adult
- Animals
- Disease Models, Animal
- Electrophoresis, Polyacrylamide Gel
- Epidermal Growth Factor
- Female
- Genes, Recessive
- Heterozygote
- Humans
- Macromolecular Substances
- Male
- Metabolism, Inborn Errors
- Mice
- Mice, Inbred C57BL
- Middle Aged
- Molecular Weight
- Phenotype
- Polycystic Kidney Diseases