Article
Systematic HRAS amplification in ovary-independent mammary tumors: correlation with progressively anaplastic phenotypes.
Cancer research - 15 Nov 1993
Aldaz C M, Gollahon L S, Chen A
Abstract excerpt
Progression of well differentiated rat mammary adenocarcinomas to very anaplastic phenotypes was found to correlate with a systematic and significant amplification of a mutant HRAS allele. Tumors with high amplification levels of this oncogene were analyzed by chromosomal in situ hybridization; i...
Topics
- Adenocarcinoma
- Alleles
- Animals
- Antigens, Neoplasm
- Carcinoma
- Chromosome Banding
- DNA, Neoplasm
- Female
- Gene Amplification
- Genes, ras
- In Situ Hybridization
- Mammary Neoplasms, Experimental
- Methylnitrosourea
- Phenotype
- Rats
- Rats, Inbred BUF