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Article

Correction of a lysosomal deficiency by contact-mediated enzyme transfer after bone marrow transplantation.

Transplantation - 1 Oct 1993

Bou-Gharios G, Adams G, Pace P, Warden P, Olsen I

Abstract excerpt

The effectiveness of bone marrow transplantation for treating lysosomal deficiency diseases relies on the ability of bone marrow cells to provide the missing enzyme to various tissues of the recipient. This has been shown to occur in vitro by endocytosis of enzyme secreted by bone marrow-derived cells and also by direct cell-to-cell-contact. To investigate the mechanism of enzyme replacement therapy in vivo we...

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PMID: 8212223
DOI: 10.1097/00007890-199310000-00040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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