Article
Modifications in the binding domain of avian retrovirus envelope protein to redirect the host range of retroviral vectors.
Journal of virology - 1 Jul 1994
Valsesia-Wittmann S, Drynda A, Deléage G, Aumailley M, Heard J M, Danos O, Verdier G, Cosset F L
Abstract excerpt
On the basis of theoretical structural and comparative studies of various avian leukosis virus SU (surface) envelope proteins, we have identified four small regions (I, II, III, and IV) in their receptor-binding domains that could potentially be involved in binding to receptors. From the envelope gene of an avian leukosis virus of subgroup A, we have constructed a set of SU mutants in which these regions were...
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