Over-representation of the disease associated (CAG) and (CGG) repeats in the human genome.

doi:10.1093/nar/22.9.1735

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Article

Over-representation of the disease associated (CAG) and (CGG) repeats in the human genome.

Nucleic acids research - 11 May 1994

Han J, Hsu C, Zhu Z, Longshore J W, Finley W H

Abstract excerpt

Expansion of trimer repeats has recently been described as a new type of human mutation. Of the 64 possible trimer compositions, only the CGG and CAG repeats have been implicated in genetic diseases. This study intends to address two questions: (1) What makes the CGG and CAG repeats unique? (2) C...

Topics

Base Sequence
Computer Simulation
DNA
Fragile X Syndrome
Genetic Diseases, Inborn
Genome, Human
Humans
Molecular Sequence Data
Mutation
Repetitive Sequences, Nucleic Acid
Software

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