Article
Altered microtubule organization in small-calibre axons of mice lacking tau protein.
Nature - 9 Jun 1994
Harada A, Oguchi K, Okabe S, Kuno J, Terada S, Ohshima T, Sato-Yoshitake R, Takei Y, Noda T, Hirokawa N
Abstract excerpt
The tau gene encodes a protein (Tau) that is a major neuronal microtubule-associated protein localized mostly in axons. It has microtubule-binding and tubulin-polymerizing activity in vitro and is thought to make short crossbridges between axonal microtubules. Further, tau-transfected non-neurona...
Topics
- Animals
- Axons
- Cell Line
- Cloning, Molecular
- Female
- Hippocampus
- Male
- Mice
- Microtubules
- Morphogenesis
- Mutation
- Neurons
- tau Proteins