Article
The effect of anti-CD4 monoclonal antibody treatment on immunopathological changes in psoriatic skin.
Journal of dermatological science - 1 Feb 1994
Rizova H, Nicolas J F, Morel P, Kanitakis J, Demidem A, Revillard J P, Wijdenes J, Thivolet J, Schmitt D
Abstract excerpt
Recent clinical studies which showed the therapeutic effect of cyclosporin A and of anti-CD4 MoAb emphasized the role of activated CD4+ T cells infiltrating the lesional skin in the pathogenesis of psoriasis. The aim of the present study was to analyze the mode of action of anti-CD4 MoAb in 3 psoriatic patients who experienced an anti-CD4 MoAb-induced clinical improvement maximal 3-4 weeks after the onset of an...
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