The effect of anti-CD4 monoclonal antibody treatment on immunopathological changes in psoriatic skin.

doi:10.1016/0923-1811(94)90016-7

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Article

The effect of anti-CD4 monoclonal antibody treatment on immunopathological changes in psoriatic skin.

Journal of dermatological science - 1 Feb 1994

Rizova H, Nicolas J F, Morel P, Kanitakis J, Demidem A, Revillard J P, Wijdenes J, Thivolet J, Schmitt D

Abstract excerpt

Recent clinical studies which showed the therapeutic effect of cyclosporin A and of anti-CD4 MoAb emphasized the role of activated CD4+ T cells infiltrating the lesional skin in the pathogenesis of psoriasis. The aim of the present study was to analyze the mode of action of anti-CD4 MoAb in 3 pso...

Topics

Adult
Antibodies, Monoclonal
CD4 Antigens
Humans
Immunohistochemistry
Immunotherapy
Keratinocytes
Male
Middle Aged
Phenotype
Psoriasis
Skin
T-Lymphocyte Subsets

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