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Article

Axonemes paralyzed by the presence of dyneins unable to use ribose-modified ATP.

Cell motility and the cytoskeleton - 1 Jan 1994

Lark E, Omoto C K

Abstract excerpt

Substrate analogs are useful for studying the structures of active sites and for distinguishing between similar enzyme activities. Fluorescent ribose-modified ATP analogs were used to investigate the functional differences between dynein ATPases. These analogs reactivate (support the movement of) sea urchin sperm axonemes, yet they do not reactivate wild-type Chlamydomonas axonemes. Surprisingly, the analogs...

Topics

Adenosine Triphosphate
Animals
Binding Sites
Binding, Competitive
Cell Movement
Chlamydomonas reinhardtii
Dyneins
Kinetics
Microtubules
Mutation
Substrate Specificity
ortho-Aminobenzoates

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 8162622
DOI: 10.1002/cm.970270207

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8162622-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Axonemes paralyzed by the presence of dyneins unable to use ribose-modified ATP.PMID 8162622Read ↗

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Dynein pulls microtubules without rotating its stalk.Semantic proximity Read ↗

Structural and functional reconstitution of inner dynein arms in Chlamydomonas flagellar axonemes.Semantic proximity Read ↗

Targeted dynein inhibition generates flagellar beatingSemantic proximity Read ↗

Strikingly low ATPase activities in flagellar axonemes of a Chlamydomonas mutant missing outer dynein arms.Semantic proximity Read ↗

Reactivation at low ATP distinguishes among classes of paralyzed flagella mutants.Semantic proximity Read ↗

Central pair apparatus enhances outer-arm dynein activities through regulation of inner-arm dyneins.Semantic proximity Read ↗

Mutations in the "dynein regulatory complex" alter the ATP-insensitive binding sites for inner arm dyneins in Chlamydomonas axonemes.Semantic proximity Read ↗

Bending patterns of ATP-reactivated sea urchin sperm flagella following high salt extraction for removal of outer dynein arms.Semantic proximity Read ↗

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Beat frequency difference between the two flagella of Chlamydomonas depends on the attachment site of outer dynein arms on the outer-doublet microtubules.Semantic proximity Read ↗

Functional reconstitution of Chlamydomonas outer dynein arms from alpha-beta and gamma subunits: requirement of a third factor.Semantic proximity Read ↗

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