Cultured skin fibroblasts derived from three patients with disseminated superficial actinic porokeratosis (DSAP) are hypersensitive to the lethal effects of X-radiation but not to those of ultraviolet (UV) light.

Abstract excerpt

Disseminated superficial actinic porokeratosis (DSAP), skin lesions of which are known to be induced by ultraviolet (UV) light, does not develop into skin cancer as frequently as other types of porokeratosis (PK). To establish the cellular basis of this characteristic of DSAP, we examined the colony-forming ability of UVC light- or X-ray-irradiated cultured fibroblasts derived from DSAP patients' skin....

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