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Article

Cephalometric evidence for a dominantly inherited predisposition to cleft lip-cleft palate in a single large kindred.

American journal of medical genetics - 1 Mar 1994

Ward R E, Bixler D, Jamison P L

Abstract excerpt

Several studies have demonstrated an association between facial shape in parents and the presence of oral clefts in their offspring. However, these observations have been of little practical value because it has been assumed that facial shape was just one predisposing component among many in a multifactorial model of inheritance. Cephalometric analysis of a large family with 5 generations of affected individuals...

Topics

Cephalometry
Cleft Lip
Cleft Palate
Discriminant Analysis
Disease Susceptibility
Female
Genes, Dominant
Genetic Carrier Screening
Humans
Male
Multivariate Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pedigree

Phenotype

Physiognomy

Risk Factors

Source

Identifiers

PMID: 8160754
DOI: 10.1002/ajmg.1320500113

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8160754-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Cephalometric evidence for a dominantly inherited predisposition to cleft lip-cleft palate in a single large kindred.PMID 8160754Read ↗

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