Article
Inactivation of antibiotics and the dissemination of resistance genes.
Science (New York, N.Y.) - 15 Apr 1994
Davies J
Abstract excerpt
The emergence of multidrug-resistant bacteria is a phenomenon of concern to the clinician and the pharmaceutical industry, as it is the major cause of failure in the treatment of infectious diseases. The most common mechanism of resistance in pathogenic bacteria to antibiotics of the aminoglycoside, beta-lactam (penicillins and cephalosporins), and chloramphenicol types involves the enzymic inactivation of the...
Topics
- Amino Acid Sequence
- Aminoglycosides
- Anti-Bacterial Agents
- Chloramphenicol O-Acetyltransferase
- Drug Resistance, Microbial
- Gene Transfer Techniques
- Genes, Bacterial
- Molecular Sequence Data
- Mutation
- R Factors
- Recombination, Genetic