Absence of myotonic dystrophy in southern African Negroids is associated with a significantly lower number of CTG trinucleotide repeats.

doi:10.1136/jmg.31.1.37

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Article

Absence of myotonic dystrophy in southern African Negroids is associated with a significantly lower number of CTG trinucleotide repeats.

Journal of medical genetics - 1 Jan 1994

Goldman A, Ramsay M, Jenkins T

Abstract excerpt

Myotonic dystrophy (DM) is associated with an increased number of CTG repeats in the 3' untranslated region of the myotonin gene. Because DM has not been observed in southern African Negroids, a study of the CTG repeat polymorphism in this population was undertake. A total of 210 unrelated subjec...

Topics

Africa, Southern
Alleles
Black People
Humans
Myotonic Dystrophy
Polymerase Chain Reaction
Repetitive Sequences, Nucleic Acid

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