Article
In vitro selection of human rhinovirus relatively resistant to soluble intercellular adhesion molecule-1.
Antimicrobial agents and chemotherapy - 1 Jan 1994
Arruda E, Crump C E, Hayden F G
Abstract excerpt
Variants of human rhinovirus serotype 39 (HRV-39) relatively resistant to inhibition by soluble intercellular adhesion molecule-1 (sICAM-1) were selected by serial passages in HeLa or WI-38 cells in the presence of sICAM-1. Moderate resistance (four- to fivefold increases in 50% effective inhibitory concentrations [EC50s]) was observed after the second passage in HeLa cells and remained constant during six...
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