Article
The E6/E7 promoter of extrachromosomal HPV16 DNA in cervical cancers escapes from cellular repression by mutation of target sequences for YY1.
The EMBO journal - 15 Mar 1994
May M, Dong X P, Beyer-Finkler E, Stubenrauch F, Fuchs P G, Pfister H
Abstract excerpt
Human papillomavirus type 16 (HPV16) induces squamous intraepithelial lesions of the cervical mucosa which may develop into invasive cancer. The expression of viral oncogenes in advanced neoplasias appears increased relative to the proliferating cell layers of low grade lesions raising questions...
Topics
- Base Sequence
- Binding Sites
- Chromosomes, Human
- DNA, Viral
- DNA-Binding Proteins
- Erythroid-Specific DNA-Binding Factors
- Female
- Gene Expression Regulation, Viral
- Humans
- Molecular Sequence Data
- Mutation
- Oncogene Proteins, Viral
- Papillomaviridae
- Papillomavirus E7 Proteins