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Article

Interferon (IFN)-alpha 2 genotype analysis of Chinese chronic hepatitis B patients undergoing recombinant IFN-alpha 2a therapy.

The Journal of infectious diseases - 1 Apr 1994

Crowe J S, Gewert D R, Barber K A, Lewis A P, Sims M J, Davies S L, Salom C L, Wood J, Thomas H C, Thursz M

Abstract excerpt

Sixteen Chinese chronic hepatitis B virus (HBV)-infected patients were treated with recombinant interferon-alpha 2a (rIFN-alpha 2a). Of these, 8 made a response to IFN, with titers of neutralizing antibody of 141-4525 as determined by an antiviral neutralization bioassay. To determine whether the immunogenicity of the IFN was directly linked to the patients' genotype, their genomic DNA was analyzed for the...

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Identifiers

PMID: 8133104
DOI: 10.1093/infdis/169.4.875

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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