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Article

Journal of Bone and Mineral Research

1 Dec 1993

Abstract excerpt

The presence of growth and differentiation factors in bone has been demonstrated by subcutaneous implantation of demineralized bone matrix that initiates new cartilage and bone morphogenesis. The genes for bone morphogenetic proteins (BMPs) have been cloned and expressed. Recombinant BMPs induce endochondral bone formation in vivo. The multistep sequential developmental cascade consists of chemotaxis, mitosis,...

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PMID: 8122519
DOI: 10.1002/jbmr.5650081313

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