Article
Effect of estradiol on tumor growth, cell kinetics and p53 oncoprotein expression in human endometrial adenocarcinoma heterotransplanted into nude mice.
In vivo (Athens, Greece) - 1 Jan 2000
Horvath G, Baldetorp B, Fernö M, Johansson M, Nesland J, Tropé C
Abstract excerpt
To study the importance of estradiol concentrations in which tumors are growing to progression of tumor growth and cell kinetics, we have used a human tumor-nude mice model. In this model a human endometrial adenocarcinoma with estradiol independent but estradiol-responsive growth phenotype (i.e....
Topics
- Animals
- Carcinoma, Endometrioid
- Cell Division
- DNA, Neoplasm
- Estradiol
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Mice
- Mice, Nude
- Neoplasm Proteins
- Neoplasm Transplantation
- Phenotype
- Receptors, Estrogen
- Receptors, Progesterone
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53