Article
Inactivation of the Porphyromonas gingivalis fimA gene blocks periodontal damage in gnotobiotic rats.
Journal of bacteriology - 1 Feb 1994
Malek R, Fisher J G, Caleca A, Stinson M, van Oss C J, Lee J Y, Cho M I, Genco R J, Evans R T, Dyer D W
Abstract excerpt
Fimbrial production by Porphyromonas gingivalis was inactivated by insertion-duplication mutagenesis, using the cloned gene for the P. gingivalis major fimbrial subunit protein, fimA. by several criteria, this insertion mutation rendered P. gingivalis unable to produce fimbrilin or an intact fimb...
Topics
- Alveolar Bone Loss
- Animals
- Bacterial Adhesion
- Bacterial Proteins
- Blotting, Western
- Conjugation, Genetic
- Durapatite
- Fimbriae Proteins
- Genes, Bacterial
- Germ-Free Life
- Hemagglutination Tests
- Male
- Mutagenesis, Insertional
- Mutation
- Plasmids