Article
A silent mutation in HLA-DPB1*0101 and its evolutionary implications.
Human immunology - 1 Oct 1993
Meyer C G, Schnittger L
Abstract excerpt
A novel HLA-DPB1 allele (DPB1*/A6) has been identified in West Africa, and the occurrence of the recently reported allele DPB1*4001 (DPB1*BRI-5) in Negroid populations has been confirmed DPB1*WA6 differs from DPB1*0101 by a silent nucleotide exchange at codon position 43 only. It constitutes, thereby, a link to DPB1*1101, *1501, and *2601 and suggests and evolutionary relationship with these alleles. Carrying the...
Topics
- Alleles
- Base Sequence
- HLA-DP Antigens
- HLA-DP beta-Chains
- Humans
- Liberia
- Molecular Sequence Data
- Mutation
- Phylogeny
- Polymerase Chain Reaction
