Article
HLA-DR, -DQ and -DP alleles in nickel, chromium, and/or cobalt-sensitive individuals: genomic analysis based on restriction fragment length polymorphisms.
The Journal of investigative dermatology - 1 Mar 1993
Emtestam L, Zetterquist H, Olerup O
Abstract excerpt
The increased concordance rate of nickel sensitivity in monozygotic compared to dizygotic twins indicates a genetic causal component. We have previously described an association in nickel-sensitive subjects with an HLA-DQA restriction fragment length polymorphism (RFLP) (4.5-kb TaqI band, DQA1*05...
Topics
- Alleles
- Chromium
- Cobalt
- Dermatitis, Allergic Contact
- Female
- Genes, MHC Class II
- HLA-D Antigens
- HLA-DP Antigens
- HLA-DQ Antigens
- HLA-DR Antigens
- Haplotypes
- Humans
- Male
- Nickel
- Polymorphism, Restriction Fragment Length