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Article

Genetic relationships determined by a DNA heteroduplex mobility assay: analysis of HIV-1 env genes.

Science (New York, N.Y.) - 19 Nov 1993

Delwart E L, Shpaer E G, Louwagie J, McCutchan F E, Grez M, Rübsamen-Waigmann H, Mullins J I

Abstract excerpt

The genetic diversity of human immunodeficiency virus (HIV) is a major concern thought to impact on immunologic escape and eventual vaccine efficacy. Here, simple and rapid methods are described for the detection and estimation of genetic divergence between HIV strains on the basis of the observation that DNA heteroduplexes formed between related sequences have a reduced mobility in polyacrylamide gels...

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Source

Identifiers

PMID: 8235655
DOI: 10.1126/science.8235655

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