Article
Genetic relationships determined by a DNA heteroduplex mobility assay: analysis of HIV-1 env genes.
Science (New York, N.Y.) - 19 Nov 1993
Delwart E L, Shpaer E G, Louwagie J, McCutchan F E, Grez M, Rübsamen-Waigmann H, Mullins J I
Abstract excerpt
The genetic diversity of human immunodeficiency virus (HIV) is a major concern thought to impact on immunologic escape and eventual vaccine efficacy. Here, simple and rapid methods are described for the detection and estimation of genetic divergence between HIV strains on the basis of the observa...
Topics
- Acquired Immunodeficiency Syndrome
- Africa
- Base Sequence
- Democratic Republic of the Congo
- Electrophoresis, Polyacrylamide Gel
- Genes, env
- Genetic Variation
- HIV Infections
- HIV-1
- Humans
- Molecular Epidemiology
- Molecular Sequence Data
- North America
- Nucleic Acid Heteroduplexes
- Phylogeny
- Polymerase Chain Reaction