Article
Biological characterization of bovine herpesvirus 1 recombinants possessing the vaccine glycoprotein E negative phenotype.
Veterinary microbiology - 31 Mar 2006
Muylkens Benoît, Meurens François, Schynts Frédéric, de Fays Katalin, Pourchet Aldo, Thiry Julien, Vanderplasschen Alain, Antoine Nadine, Thiry Etienne
Abstract excerpt
Intramolecular recombination is a frequent event during the replication cycle of bovine herpesvirus 1 (BoHV-1). Recombinant viruses frequently arise and survive in cattle after concomitant nasal infections with two BoHV-1 mutants. The consequences of this process, related to herpesvirus evolution, have to be assessed in the context of large use of live marker vaccines based on glycoprotein E (gE) gene deletion....
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