Malignant meningioma in Gorlin's syndrome: cytogenetic and p53 gene analysis. Case report.

doi:10.3171/jns.1994.81.3.0466

Back to search

Article

Malignant meningioma in Gorlin's syndrome: cytogenetic and p53 gene analysis. Case report.

Journal of neurosurgery - 1 Sept 1994

Albrecht S, Goodman J C, Rajagopolan S, Levy M, Cech D A, Cooley L D

Abstract excerpt

Gorlin's syndrome, also known as multiple basal cell carcinoma syndrome, is a familial tumor condition with autosomal-dominant inheritance. Patients develop multiple basal cell carcinomas beginning in childhood. They also have a typical dysmorphic facies, skeletal malformations, and a particular type of epithelial cyst of the jaws. Recent evidence localizes a Gorlin's syndrome locus on chromosome 9 at band q31....

Topics

Adult
Basal Cell Nevus Syndrome
Brain Neoplasms
Chromosomes, Human, Pair 9
Female
Genes, p53
Humans
Karyotyping
Male
Meningioma
Middle Aged
Mutation

Translocation, Genetic

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest

Malignant meningioma in Gorlin's syndrome: cytogenetic and p53 gene analysis. Case report.PMID 8057157Read

Detection of Chromosomal Imbalances in Spinal Meningiomas by Comparative Genomic Hybridization.Semantic proximity Read

Developmental defects in Gorlin syndrome related to a putative tumor suppressor gene on chromosome 9.Semantic proximity Read

Gorlin syndrome: A case reportSemantic proximity Read

Beta-catenin mutations in craniopharyngiomas and pituitary adenomas.Semantic proximity Read

Gorlin's syndrome: main features and recent advances.Semantic proximity Read

The genetics of pediatric brain tumors.Semantic proximity Read

Pathology and Molecular Genetics of Meningioma: Recent AdvancesSemantic proximity Read

Multiple tumor types including leiomyoma and Wilms tumor in a patient with Gorlin syndrome due to 9q22.3 microdeletion encompassing the PTCH1 and FANC-C loci.Semantic proximity Read