Developmental defects in Gorlin syndrome related to a putative tumor suppressor gene on chromosome 9.

doi:10.1016/0092-8674(92)90122-s

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Article

Developmental defects in Gorlin syndrome related to a putative tumor suppressor gene on chromosome 9.

Cell - 3 Apr 1992

Gailani M R, Bale S J, Leffell D J, DiGiovanna J J, Peck G L, Poliak S, Drum M A, Pastakia B, McBride O W, Kase R

Abstract excerpt

Gorlin syndrome is an autosomal dominant disorder that predisposes to basal cell carcinomas of the skin, ovarian fibromas, and medulloblastomas. Unlike other hereditary disorders associated with cancer, it features widespread developmental defects. To investigate the possibility that the syndrome...

Topics

Basal Cell Nevus Syndrome
Chromosomes, Human, Pair 9
Female
Genes, Tumor Suppressor
Genetic Linkage
Heterozygote
Humans
Male
Mutation
Pedigree
Polymorphism, Restriction Fragment Length

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