Autoimmune polyglandular disease type I. Exclusion map using amplifiable multiallelic markers in a microtiter well format.

Article

Autoimmune polyglandular disease type I. Exclusion map using amplifiable multiallelic markers in a microtiter well format.

European journal of human genetics : EJHG - 1 Jan 1993

Aaltonen J, Komulainen J, Vikman A, Palotie A, Wadelius C, Perheentupa J, Peltonen L

Abstract excerpt

The pathogenetic background of human autoimmunity is only partially understood. By discovering the defective gene causing the autosomal recessive polyglandular autoimmune disease type I (PGD I, APECED) we hope to provide new insights into autoimmune responses in general. Here we have taken advantage of newly developed amplifiable multiallelic microsatellite markers and performed the analyses using the microtiter...

Topics

Alleles
Chromosome Mapping
Chromosomes, Human, Pair 22
Female
Genetic Linkage
Humans
Male
Pedigree
Polyendocrinopathies, Autoimmune
Polymerase Chain Reaction
Polymorphism, Genetic

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