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Article

Antibody-mediated complement activation on nucleated cells. A quantitative analysis of the individual reaction steps.

1 Sept 1994

Abstract excerpt

The sequential molecular events of the initiation, amplification, and membrane attack phases of classical C pathway activation on nucleated cells were investigated. As a model system, C-susceptible human melanoma cells (SK-MEL-93-2) expressing the disialoganglioside Ag GD3 were studied. Activation of the classical C pathway was initiated by the anti-GD3 mAb R24 (murine IgG3). The initiation phase is characterized...

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PMID: 8051421
DOI: 10.4049/jimmunol.153.5.2213

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