Article
Virulence of patient and water isolates of Legionella pneumophila in guinea pigs and mouse L929 cells varies with bacterial genotype.
Canadian journal of microbiology - 1 Jun 1994
Bezanson G, Fernandez R, Haldane D, Burbridge S, Marrie T
Abstract excerpt
Thirteen isolates of Legionella pneumophila serogroup 1 (five from patients, eight from water) were screened for their virulence in guinea pigs after intraperitoneal injection and for their infectivity in L929 mouse cells. Since these isolates included three monoclonal antibody subtypes and four genotypes, the relative influence of these parameters on the pathogenicity of naturally occurring L. pneumophila could...
Topics
- Animals
- DNA, Bacterial
- Genotype
- Guinea Pigs
- Humans
- L Cells
- Legionella pneumophila
- Legionnaires' Disease
- Lethal Dose 50
- Mice
- Serotyping