Computer simulated evolution of a network of cell-signaling molecules.

doi:10.1016/S0006-3495(94)80878-1

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Article

Computer simulated evolution of a network of cell-signaling molecules.

Biophysical journal - 1 Apr 1994

Bray D, Lay S

Abstract excerpt

We have trained a computer model of a simple cell-signaling pathway to give specified responses to a pulse of an extracellular ligand. The pathway consists of two initially identical membrane receptors, each of which relays the concentration of the ligand to the level of phosphorylation of an intracellular molecule. Application of random "mutational" changes to the rate constants of the pathway, followed by...

Topics

Algorithms
Biological Evolution
Biophysical Phenomena
Biophysics
Cell Membrane
Chemotaxis
Computer Simulation
Cytosol
Escherichia coli
Models, Biological
Mutation
Receptors, Cell Surface

Signal Transduction

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